Document 0479
 DOCN  M9480479
 TI    Polymerase chain reaction for rapid diagnosis of tuberculous meningitis
       in AIDS patients.
 DT    9410
 AU    Folgueira L; Delgado R; Palenque E; Noriega AR; Department of
       Microbiology, Hospital Doce de Octubre, Madrid,; Spain.
 SO    Neurology. 1994 Jul;44(7):1336-8. Unique Identifier : AIDSLINE
       MED/94309824
 AB    We used a test based on the polymerase chain reaction (PCR) for the
       detection of Mycobacterium tuberculosis DNA in 11 CSF samples from 10
       HIV-seropositive patients in whom tuberculous meningitis was suspected.
       PCR was positive in nine samples from eight patients in whom clinical
       data, CSF findings, evidence of tuberculosis at an extraneural site, and
       response to antituberculous drug therapy supported the diagnosis,
       whereas cultures were positive in five of these nine samples and
       staining in only one. The PCR was negative in 14 CSF samples from the
       control group.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult  Base Sequence
       DNA, Bacterial/CEREBROSPINAL FLUID  Female  Human  Male  Molecular
       Probes/GENETICS  Molecular Sequence Data  Mycobacterium
       tuberculosis/GENETICS  *Polymerase Chain Reaction  Support, Non-U.S.
       Gov't  Time Factors  Tuberculosis, Meningeal/*DIAGNOSIS/ETIOLOGY
       JOURNAL ARTICLE

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